Crystallo-co-Agglomeration Technique for Improving Physicochemical Properties, Compressibility and Solubility Characteristics of Metronidazole

The objective of this study is to develop crystallo-co-agglomeratesof metronidazole having improved physicochemical, compressibility andsolubility properties. process agglomeration employed the use ofdichloromethane (good solvent), ethanol (bridging liquid) and distilled water (poorsolvent). Micromeritic properties co-agglomerates werestudied in terms bulk density, tapped Carr's index, Hausner’sratio, angle repose. Co-agglomerates were also subjected compactionstudies using Heckel Kawakita compaction models. Characterisation ofthe agglomerates was studied Scanning electronic microscopy, Fourier-transformed infrared spectroscopy, X-ray diffraction. co-agglomerateswere further evaluated for drug release profile. micrometric anddissolution characteristics significantlyimproved when compared pure metronidazole. repose formetronidazole found be 29.77°±1.09, Carr’s index was13.60±0.35, Hausner’s ratio 1.15±0.06, indicating good flow ability. Thedrug released over a period 30 min 102.61%, shows better drugrelease than drug, could due solubilization inpresence hydrophilic polymers. It can concludedthat successfully prepared crystallo-co-agglomeration technique with properties, excellentcompressibility, solubility characteristics.